Could Concurrent Use of Herbal Medicinal Products and Prescription DrugsRaise Older Adults Risk of Vascular Dementia
The Journal of Clinical Toxicology (JCT) is Scholarly Open Access journal that deals with the study of xenobiotics and alsostudy toxic effects of agents (drugs) whose purpose is to ameliorate or prevent a disease. The journal addresses both scientific research and clinical advances in clinical toxicology. This free clinical journal provides an open access platform for researcher’s work in clinical toxicology in hospitals, academia, government or industrial sectors.
This Scientific journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing. The journal is using Editorial Tracking System for quality peer-review process. Editorial Tracking is an online manuscript submission, review and Managing systems. Review processing is performed by the editorial board members of Journal of Clinical Toxicology or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Journal of Clinical Toxicology aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide.Excellent contributions are welcome to receive high impact factor for this scholarly journal.
JCT has recently released article entitled “Could Concurrent Use of Herbal Medicinal Products and Prescription DrugsRaise Older Adults Risk of Vascular Dementia” whose abstract is as follows:
While the role of chemical insults or the buildup of chemical insults in cardiovascular pathogenesis continuouslydraws attention, the potential interference of a variety of currently used or investigational drugs on the ability ofendothelial cells (ECs) which are responsible for providing a unique surface to allow the cellular elements of blood toflow without adhering to the vessel lining has been much less appreciated in drug discovery research. Activated ECsare more sensitive to long-term, continuous drug exposure than normal cells. Prolonged activation of ECs predisposesthe blood vessel wall to vasoconstriction, leukocyte adherence, platelet activation, thrombosis, impaired coagulation,vascular inflammation, pro-oxidation, and atherosclerosis. The studies of hypercholesterolemia, homocystinemia,hyperglycemia, hypertension, smoking, inflammation, aging, diabetes mellitus, and heart rhythm abnormalitiesfurther lend credence for the contribution of perturbed EC structure and function in the development of heartattacks. These risk factors are often established in elders living with one or more chronic diseases and to some extenthold true across all adult age groups. Evidence indicates that vascular reactivity is an independent risk factor fordementia. Most people who have exhibited vascular dementia following a stroke had a high blood pressure ordiabetes prior to the occurrence. Often adults with chronic diseases are treated with long-term, continuous,prescription drug(s) and self-administration of traditional medicines. Thus, an assessment of a combination oftraditional medicines with widely used prescription drugs on activated ECs should be tested in experimental animalmodels of these diseases to demonstrate whether the long-term exposure of this combination therapy exacerbatesvascular reactivity and worsens ischemic perfusion defect.
Keywords: Vascular dementia; Activated Endothelial Cells; Cardiovascular pathogenesis
Journal of Clinical Toxicology
Mail ID: firstname.lastname@example.org