Disorders of Follicular Occlusion include the conditions Hidradenitis Suppurativa (HS), Dissecting Cellulitis of the Scalp (DCS), Acne Congolobata (AC) and Pilonidal Sinus Disease (PD). All of these disorders are chronic, burdensome diseases with few efficacious therapeutic options. The prevailing pathogenic paradigm in these disorders are follicular occlusion via a variety of endogenous and exogenous mechanisms, resulting in follicular rupture and dermal inflammatory response.
The term ‘disorders of follicular occlusion’ was first coined in 1956 by Pillsbury, Shelley and Kligman based upon commonalities in histopathological and clinical manifestations. However, since this time our understanding of follicular biology, physiology and cutaneous immunology has expanded dramatically. Paradigm shifts in our understanding of the mechanistic underpinnings of other dermatological disorders (such as psoriasis and atopic dermatitis) have led to translational revolutions and the development of novel therapeutics.
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Hair Therapy and Transplantation