Cancer is currently the second most common cause of death worldwide and it is projected to become the most common cause of death in the near future based on current trends. Human chromosome 8q24 is a well-established region of genomic instability and cancer susceptibility. While poor in protein-coding genes, it is rich in non-coding genes. One non-protein coding gene located downstream of MYC at chromosome 8q24 is PVT1. The PVT1 non-protein coding gene has been implicated in very many cancers, including cervical cancer, bladder cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, breast cancer, ovarian cancer, acute myeloid leukemia and Hodgkin’s lymphoma. It encodes six annotated microRNAs (miR-1204, miR-1205, miR-1206, miR-1207-3p, miR-1207-5-p, and miR-1208), some of which are also being implicated in carcinogenesis. Thus, PVT1 is emerging as a major player in cancer. This article collection will compile in one location the most recent and up to date information on the emerging role of PVT1 in various cancers..
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Journal of Medical and surgical pathology