Recent Outcomes in the Prevention and Treatment of Herpes Simplex
The herpes simplex virus causes herpes simplex, which is a viral ailment. Infections are classified according to the part of the body that is infected. Oral herpes affects the mouth and face. It might cause little blisters in groups, which are known as cold sores or fever blisters, or it can just create a sore throat.
Genital herpes, often simply known as herpes, may have minimal symptoms or form blisters that break open and result in small ulcers. These typically heal over two to four weeks. Tingling or shooting pains may occur before the blisters appear. Herpes cycles between periods of active disease followed by periods without symptoms. The first episode is often more severe and may be associated with fever, muscle pains, swollen lymph nodes and headaches. Over time, episodes of active disease decrease in frequency and severity.
There are two types of herpes simplex virus, type 1 (HSV-1) and type 2 (HSV-2). HSV-1 more commonly causes infections around the mouth while HSV-2 more commonly causes genital infections. They are transmitted by direct contact with body fluids or lesions of an infected individual. Transmission may still occur when symptoms are not present. Genital herpes is classified as a sexually transmitted infection. It may be spread to an infant during childbirth. After infection, the viruses are transported along sensory nerves to the nerve cell bodies, where they reside lifelong.
The first outbreak of herpes simplex is often the worst. Not all first outbreaks are severe, though. Some are so mild that a person does not notice. When the first outbreak of genital herpes is mild and another outbreak happens years later, the person can mistake it for a first outbreak. Some people have one outbreak. For others, the virus becomes active again. When they have another outbreak, it is called a recurrence. These tend to be more common during the first year of infection. Over time, the outbreaks tend to become less frequent and milder. This is because the body makes antibodies to the virus.
As with almost all sexually transmitted infections, women are more susceptible to acquiring genital HSV-2 than men. On an annual basis, without the use of antivirals or condoms, the transmission risk of HSV-2 from infected male to female is about 8–11%. This is believed to be due to the increased exposure of mucosal tissue to potential infection sites. Transmission risk from infected female to male is around 4–5% annually. Suppressive antiviral therapy reduces these risks by 50%. Antivirals also help prevent the development of symptomatic HSV in infection scenarios, meaning the infected partner will be seropositive but symptom-free by about 50%. Condom use also reduces the transmission risk significantly. Condom use is much more effective at preventing male-to-female transmission than vice versa. Previous HSV-1 infection may reduce the risk for acquisition of HSV-2 infection among women by a factor of three, although the one study that states this has a small sample size of 14 transmissions out of 214 couples.
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