Transcriptomics of Single Cell: New Discoveries to Become Basis for Future Studies

Image

Single-cell transcriptome profiling has been an indispensable tool used for determining cell type, transcriptomic signatures, and single cell transcriptomics of ncRNAs. Нis technique could bring about a paradigm shiі in disease management and could even become the basis of further studies.

to study the expression levels of mRNAs in a cell. Transcriptome, which is an umbrella term for all RNA molecules, play a vital role in studying human tissues at the cellular level, as it is a dynamic and good representative of the cellular state. Нis make it an indispensable tool to understand how genes are expressed and interconnected.

Numerous studies have been conducted across the globe to discern the nuances of the genetic make-up alongside making new breakthroughs in the field of genetics. In line with this trend, private organizations such as Нermo Fisher 6cientific, Inc. have taken significDnt proactive steps to make inroads in disease profiling and treatment using novel techniques. For instance, Нermo Fisher 6cientificͤs Ion Torrent Transcriptome 3rofiling Grant Program focuses on the importance of a conducting gene-level expression analysis for discovering novel biomarkers, which essentially play a vital part in prognostics, cancer diagnostics, and experimental therapy. Moreover, research and development activities focusing on the role of transcriptomes in single cells have been gaining momentum lately, which makes this field lucrative for investment. According to a research firm, Allied Market Research, the global transcriptomics market is pegged to reach $7.95 billion by 2023, which could be attributed to the surge in funding by private and government organizations for R&D activities. Нus, current breakthroughs from major research activities in the field of transcriptomics would become the basis for future research.

According to two new studies published in the Science journal, single-cell transcriptome profiling can be used to determine the cell type and cell lineages of a whole complex animal. In both the studies, researchers have used Drop-seq, a high-throughput trDnscriptomeprofiling platform, to study cell types in a model organism, Schmidtea mediterranea. Нis platform was developed in collaboration with Harvard University and the Broad Institute. Furthermore, researchers from the Massachusetts Institute of Technology and the Whitehead Institute for Biomedical Research were able to identify the transcriptomes from each cell type of S. mediterranea. Moreover, they could sequence nearly 50,000 single cells alongside determining nearly 44 distinct major cell clusters and nearly 150 sub-clusters. Researchers expressed that, "Much like the genome of an animal, we propose this atlas-like dataset of cell-type transcriptomes can serve as a resource fueling an immense amount of research, not only in planarians, but in other bilaterians with similar cell types". In a similar study, researchers from Berlin’s Max-Delbrück Center for Molecular Medicine, Germany were able to create a cell type atlas for S. mediterranea and even forming a lineage tree. Нe\ were able to sequence nearly 20,000 individual cells as well determine nearly 51 cell clusters and 23 cell lineages.

Media Contact:
Rooba
Journal Manager
Transcriptomics: Open Access
Email: editor.toa@jpeerreview.com
Whatsapp Number:
+1-947-333-4405